To identify and analyse static and fatigue strength of the fasteners in the hybrid structure, detailed stress and damage analyses are required. In this report, the method of sub-modelling is presented. In this method, both the material and geometrical none-linearity are considered together with friction conditions at the fastener joints. The sub-modelling uses the boundary condition obtained from a coarse global model. According to the Saint-Venan principle, this method may provide an accurate way to deal with complex structural analyses when it is not practical to deal globally with all the none-linear issues. With the experimental data as a validation benchmark, the non-linear computational parameters as well as some important material data have been determined for the sub-modelling of the hybrid fastener joints. The progressive damage model available in the commercial code of ABAQUS is explored in details to provide knowledge for the application of the code to strength analyses of structural problems according to the multi-scale sub-modelling concept.