The research programme Weapons and protection covers several different technology areas. The work in it is based on experiments in small and large scales as well as detailed studies of future weapons effects and protective mechanisms in addition to assessment of modern complex weapon and protection systems. In order to facilitate cooperation between projects in the programme focus areas have been defined. These are intended to act as a platform for information sharing and joint work. One of these focus areas are Effects on ballistic missiles and cruise missiles. The work in this field started already before the focus areas were defined, by several projects defining a common generic missile, called iRobot. The leading idea was to develop cooperation, current tools and methodologies in the field by using a common generic model. This work is ongoing, and 2020-2022 it is focusing on the duel between air defence missiles and the incoming threats, e.g. ballistic missiles or cruise missiles. This status report gives a short and brief overview of the activities in some of the projects with work related to the focus area. There is a lead project defined for each focus area, and for this focus area, it is the vulnerability and lethality assessment project that is lead. The report also summarizes some of the challenges that differentiate the effectiveness analysis when both the warhead and target might have high velocities. A few example simulations are finally described. These were done in order to illustrate the abilities of a new version (still being developed) of the AVAL tool when it comes to determine hit probabilities and impact velocities for fragments from a warhead against an incoming threat missile.